Neurobiochemistry group, whose PI is Prof. Dr. Arantxa Tabernero, is a Recognised Research Group (GIR) Knowledge Transfer Group (GTC) at the University of Salamanca and a Consolidated Research Unit (UIC-13) of the Junta de Castilla y León in Spain. at the University of Salamanca and a Consolidated Research Unit (UIC-13) of the Junta de Castilla y León in Spain.
The group is working on numerous national and regional research projects that allow further research on the different effects of the TAT-Cx43 peptide. The projects and scientific production of the research group can be consulted at this link.
The group collaborates both nationally and internationally with the most prominent research centres, Universities and Hospitals
Our work is focused on the role played by glial cells within the nervous system in health and disease. We studied the molecular basis underlying the relationship between direct gap junctional communication mediated by connexin43 and cell proliferation. This basic research has been translated in the design of a connexin43 mimetic peptide (TAT-Cx43-266-283) with the ability to inhibit the activity of Src, an important oncoprotein involved in several signalling pathways related to cancer. Indeed, the work developed over the last few years, has demonstrated that TAT-Cx43-266-283 exerts important anti-oncogenic effects against glioblastoma, the main and more aggressive type of brain tumour, in different in vitro and in vivo models.
Neurobiochemistry group is also part of the Knowledge Transfer Group (GTC) integrated by:
Aránzazu Tabernero Urbieta (coordinator)
Asunción Morán Benito
Mónica García Domingo
José Ángel García Pedraza
Fernando Sánchez Juanes
Myriam Jaraíz Rodríguez
Raquel Flores Hernández
Paloma I. García Blázquez
Anais Clara Terol Úbeda
Funded Research
